体外研究（细胞实验）：

细胞类型（Cell type）：LNCaP prostate, SK-MES,MCF-7 and MDA-MB-231,MV-522 lung carcinoma cell lines

药物浓度（Concentration）：1000 pM for all cell lines in 3- and 5-day exposures, with the exception for500 pM paclitaxelin MDA-MB-231 for a 5-day treatment.A 10 mM stock solution of paclitaxel was prepared in 100% DMSO, and all dilutions contained 0.1% DMSO.

体外研究（细胞实验）：

细胞类型（Cell type）：CCRF-HSB-2 human T-cell lymphoblastic leukemia cell line

药物浓度（Concentration）：For MTT assay, 1 × 104 cells were plated in 100 μl of the growth medium in the presence or absence of increasing concentrations (0.1–1 μM) of taxolin 96-well plates and cultured at 37 °C in 5% CO2 for 12–48 h. The results revealed thattaxol at 0.1, 0.5, and 1 μM reduced the proliferation and survival of CCRF-HSB-2 cells in a dose-dependent fashion and that the IC50 value of taxol was about 0.25 μM.

体内研究（动物模型）：

动物模型（Animal Model）：85 nine-week old male C57BL/6J mice

注射剂量（Dosages）：20 mg PTX/kg BW,dissolved in Cremophor EL: Ethanol (1:1) with a concentration of 6 mg/ml and diluted in sterile 0.9% NaCl solution to a final concentration of 2 mg/ml before injection

给药途径（Administration）：Intraperitoneal (i.p.) injection

体内研究（动物模型）：

动物模型（Animal Model）：SCID mice xenotransplanted with human EGI-1 cells

注射剂量（Dosages）：Once tumor engraftment was confirmed by bioluminescence imaging (time 0), we started metronomic infusion ofpaclitaxel [diluted in a 50%/50% solution of Cremophor EL and ethanol (vehicle)] for 2 weeks at the dosage of 2.6 mg/kg/day by intraperitoneal injection using micro-osmotic pumps.

体外研究（细胞实验）：

细胞类型（Cell type）：LNCaP prostate, SK-MES,MCF-7 and MDA-MB-231,MV-522 lung carcinoma cell lines

药物浓度（Concentration）：1000 pM for all cell lines in 3- and 5-day exposures, with the exception for500 pM paclitaxelin MDA-MB-231 for a 5-day treatment.A 10 mM stock solution of paclitaxel was prepared in 100% DMSO, and all dilutions contained 0.1% DMSO.

体外研究（细胞实验）：

细胞类型（Cell type）：CCRF-HSB-2 human T-cell lymphoblastic leukemia cell line

药物浓度（Concentration）：For MTT assay, 1 × 104 cells were plated in 100 μl of the growth medium in the presence or absence of increasing concentrations (0.1–1 μM) of taxolin 96-well plates and cultured at 37 °C in 5% CO2 for 12–48 h. The results revealed thattaxol at 0.1, 0.5, and 1 μM reduced the proliferation and survival of CCRF-HSB-2 cells in a dose-dependent fashion and that the IC50 value of taxol was about 0.25 μM.

体内研究（动物模型）：

动物模型（Animal Model）：85 nine-week old male C57BL/6J mice

注射剂量（Dosages）：20 mg PTX/kg BW,dissolved in Cremophor EL: Ethanol (1:1) with a concentration of 6 mg/ml and diluted in sterile 0.9% NaCl solution to a final concentration of 2 mg/ml before injection

给药途径（Administration）：Intraperitoneal (i.p.) injection

体内研究（动物模型）：

动物模型（Animal Model）：SCID mice xenotransplanted with human EGI-1 cells

注射剂量（Dosages）：Once tumor engraftment was confirmed by bioluminescence imaging (time 0), we started metronomic infusion ofpaclitaxel [diluted in a 50%/50% solution of Cremophor EL and ethanol (vehicle)] for 2 weeks at the dosage of 2.6 mg/kg/day by intraperitoneal injection using micro-osmotic pumps.

体外研究（细胞实验）：

细胞类型（Cell type）：LNCaP prostate, SK-MES,MCF-7 and MDA-MB-231,MV-522 lung carcinoma cell lines

药物浓度（Concentration）：1000 pM for all cell lines in 3- and 5-day exposures, with the exception for500 pM paclitaxelin MDA-MB-231 for a 5-day treatment.A 10 mM stock solution of paclitaxel was prepared in 100% DMSO, and all dilutions contained 0.1% DMSO.

体外研究（细胞实验）：

细胞类型（Cell type）：CCRF-HSB-2 human T-cell lymphoblastic leukemia cell line

药物浓度（Concentration）：For MTT assay, 1 × 104 cells were plated in 100 μl of the growth medium in the presence or absence of increasing concentrations (0.1–1 μM) of taxolin 96-well plates and cultured at 37 °C in 5% CO2 for 12–48 h. The results revealed thattaxol at 0.1, 0.5, and 1 μM reduced the proliferation and survival of CCRF-HSB-2 cells in a dose-dependent fashion and that the IC50 value of taxol was about 0.25 μM.

体内研究（动物模型）：

动物模型（Animal Model）：85 nine-week old male C57BL/6J mice

注射剂量（Dosages）：20 mg PTX/kg BW,dissolved in Cremophor EL: Ethanol (1:1) with a concentration of 6 mg/ml and diluted in sterile 0.9% NaCl solution to a final concentration of 2 mg/ml before injection

给药途径（Administration）：Intraperitoneal (i.p.) injection

体内研究（动物模型）：

动物模型（Animal Model）：SCID mice xenotransplanted with human EGI-1 cells

注射剂量（Dosages）：Once tumor engraftment was confirmed by bioluminescence imaging (time 0), we started metronomic infusion ofpaclitaxel [diluted in a 50%/50% solution of Cremophor EL and ethanol (vehicle)] for 2 weeks at the dosage of 2.6 mg/kg/day by intraperitoneal injection using micro-osmotic pumps.

体外研究（细胞实验）：

细胞类型（Cell type）：LNCaP prostate, SK-MES,MCF-7 and MDA-MB-231,MV-522 lung carcinoma cell lines

药物浓度（Concentration）：1000 pM for all cell lines in 3- and 5-day exposures, with the exception for500 pM paclitaxelin MDA-MB-231 for a 5-day treatment.A 10 mM stock solution of paclitaxel was prepared in 100% DMSO, and all dilutions contained 0.1% DMSO.

体外研究（细胞实验）：

细胞类型（Cell type）：CCRF-HSB-2 human T-cell lymphoblastic leukemia cell line

药物浓度（Concentration）：For MTT assay, 1 × 104 cells were plated in 100 μl of the growth medium in the presence or absence of increasing concentrations (0.1–1 μM) of taxolin 96-well plates and cultured at 37 °C in 5% CO2 for 12–48 h. The results revealed thattaxol at 0.1, 0.5, and 1 μM reduced the proliferation and survival of CCRF-HSB-2 cells in a dose-dependent fashion and that the IC50 value of taxol was about 0.25 μM.

体内研究（动物模型）：

动物模型（Animal Model）：85 nine-week old male C57BL/6J mice

注射剂量（Dosages）：20 mg PTX/kg BW,dissolved in Cremophor EL: Ethanol (1:1) with a concentration of 6 mg/ml and diluted in sterile 0.9% NaCl solution to a final concentration of 2 mg/ml before injection

给药途径（Administration）：Intraperitoneal (i.p.) injection

体内研究（动物模型）：

动物模型（Animal Model）：SCID mice xenotransplanted with human EGI-1 cells

注射剂量（Dosages）：Once tumor engraftment was confirmed by bioluminescence imaging (time 0), we started metronomic infusion ofpaclitaxel [diluted in a 50%/50% solution of Cremophor EL and ethanol (vehicle)] for 2 weeks at the dosage of 2.6 mg/kg/day by intraperitoneal injection using micro-osmotic pumps.