描述
Mycophenolic Acid (MPA) 霉酚酸（麦可酚酸）
产品标签
Mycophenolic Acid (MPA) 霉酚酸；Immunosuppressive Drug 免疫抑制剂；Inosine monophosphatase dehydrogenase次黄嘌呤单核苷酸脱氢酶；IMPDH Inhibitor; Mycophenolate mofetil 吗替麦考酚酯；CAS NO：24280-93-1；
产品信息
| 产品名称 | 产品编号 | CAS NO. | 规格 | 价格（元） |
| Mycophenolic Acid (MPA) 霉酚酸（麦可酚酸） | MZ9231-0100MG | 24280-93-1 | 100mg | 298 |
| Mycophenolic Acid (MPA) 霉酚酸（麦可酚酸） | MZ9231-1000MG | 24280-93-1 | 1g | 1178 |
产品描述
霉酚酸（Mycophenolic Acid，MPA），又名麦可酚酸，是一种免疫抑制剂，用来预防器官移植后的排斥反应。MPA的功能在其是一种有效且可逆的次黄嘌呤单核苷酸脱氢酶（IMPDH）抑制剂，淋巴细胞中能阻断GTP的从头合成并引起RNA和DNA合成的减少，从而防止淋巴细胞增殖和活化，并抑制抗体生成。MPA还具有抗真菌、抗细菌、抗病毒和抗肿瘤效应。
产品特性
1）CAS NO：24280-93-1
2）化学名：6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
3）同义名：MPA;NSC 129185;
4）分子式：C17H20O6
5）分子量：320.34
6）纯度：≥98%
7）外观：白色或类白色粉末
8）溶解性：溶于乙醇、甲醇、DMSO（30mg/ml）、不溶于水
9）化学结构图：
保存与运输方法
保存：2-8ºC干燥保存，或置于-20ºC长期干燥保存，至少2年有效。
运输：室温运输。
注意事项
1）本霉酚酸（MPA）不是临床药物，只能用于科研用途，不能用于诊断或临床用途。
2）为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用方法【源自文献，仅作参考】
| 文献1，Azzarone A et al. Effects on in vivo and in vitro hepatocyte proliferation of methylprednisolone, azathioprine, mycophenolic acid, mizoribine, and prostaglandin E1. Transplant Proc. 1992 Dec;24(6):2868-71. PMID: 1465977
体外研究： 细胞类型（Cell type）：Hepatocytes (from rat liver) in Primary Culture 药物配制（Preparation）：MPA was dissolved in DMSO 实验方法（Assay）：MPA was dissolved in DMSO and added in the appropriate concentrations (0.6, 1.2, 2.4, 5, 10 μg/ml). The amount of DMSO added to the medium was never more than 2 μL/mL, which does not affect hepatocyte proliferation. The in vitro DNA synthesis was detected by [3H] Thymidine Incorporation. 体内研究： 动物模型（Animal Model）：70% partial hepatectomy rat model 药物配制（Preparation）：MPA was dissolved in 0.5% carbossil-methil-cellulose (CMC), 0.4% Tween, and 0.9% alcohol in saline. 注射剂量（Dosages）：Rats were assigned to groups and treated for 4 days as controls or with MPA (15mg/kg).On the 4th day, between 0900 and 1030 hours, the rats received a standard 70% hepatectomy under light ether anesthesia. Food and drink were allowed immediately. Twenty-four hours after the hepatectomies, 185 × 10−4Bq [3H] thymidine was administered to all rats by intraperitoneal injection. 给药途径（Administration）：Oral (p.o.) |
| 文献2，Sugiyama K et al. Peripheral Lymphocyte Response to Mycophenolic Acid In Vitro and Incidence of Cytomegalovirus Infection in Renal Transplantation. Cell Med. 2013 Oct 23;6(1-2):47-55. PMID: 26858880
体外研究： 细胞类型（Cell type）：PBMCs 药物配制（Preparation）：MPA was dissolved in Ethanol 实验方法（Assay）：PBMCs was placed into each well of a 96-well flat-bottomed microplate.Saline containing concanavalin A was added to each well to a final mitogen concentration of 5.0 µg/ml. Subsequently, an ethanol solution containing MPA was added to give a final drug concentration of 0.001, 0.01, 0.1, 1, 10, 100, 1,000, or 10,000 ng/ml. The same volume of each vehicle solution was added to the control wells (no concanavalin A or MPA treatment). After 4 days of culture, MTT assay was done. |
相关产品
| 货号 | 名称 | 规格 |
| MZ9231-0100MG | Mycophenolic Acid (MPA) 霉酚酸（麦可酚酸） | 100mg |
| MZ9232-0100MG | Mycophenolate mofetil 吗替麦考酚酯 | 100mg |
