Erastin爱拉斯汀（铁死亡激活剂）

Erastin爱拉斯汀（铁死亡激活剂）

溶剂体积

浓度

体内研究（动物模型）：

动物模型（Animal Model）：Endometriosis mouse model

实验方法（Assay）：Seven-to-8-week-old C57BL/6 female mice were obtained and 17-β-estradiol-3-benzoate (30µg/kg) was administered to each mouse every day for 3 days. We removed uterine horns from the donor mice and added them to saline. Endometrium was cut into 1mm2 fragments. The endometrial fragments from each uterine horn were suspended in 0.3ml saline and injected into the peritoneal cavities of recipient mice with an 18-gauge needle. At 8 days (5 days after the operation), endometrial-like lesions were established, and they were randomly divided into two groups (each group contained 12 mice).In the experimental group, each mouse received erastin (20mg/kg/day) by intraperitoneal injection over a 7-day period. In the control group, DMSO was used instead of erastin.At 15 days, the mice were sacrificed and endometriotic lesions were collected.

e0154605. doi: 10.1371/journal.pone.0154605. PMID: 27171435; PMCID: PMC4865238.

体内研究（动物模型）：

动物模型（Animal Model）：HT-29 tumor bearing SCID mice

实验方法（Assay）：Briefly, 2×106viable HT-29 cells in 100 μL of growth medium (per mouse) were subcutaneously inoculated, and mice bearing ~100 mm3tumors were randomly divided into three groups with 10 mice per group.Mice were treated daily with 10 or 30 mg/kg body weight of erastin (intraperitoneal injection, for 4 weeks) or vehicle control (Saline).

价格（元）

Erastin爱拉斯汀（铁死亡激活剂）

Erastin爱拉斯汀（铁死亡激活剂）

1350

2350

6350

溶剂体积

浓度

体内研究（动物模型）：

动物模型（Animal Model）：Endometriosis mouse model

实验方法（Assay）：Seven-to-8-week-old C57BL/6 female mice were obtained and 17-β-estradiol-3-benzoate (30µg/kg) was administered to each mouse every day for 3 days. We removed uterine horns from the donor mice and added them to saline. Endometrium was cut into 1mm2 fragments. The endometrial fragments from each uterine horn were suspended in 0.3ml saline and injected into the peritoneal cavities of recipient mice with an 18-gauge needle. At 8 days (5 days after the operation), endometrial-like lesions were established, and they were randomly divided into two groups (each group contained 12 mice).In the experimental group, each mouse received erastin (20mg/kg/day) by intraperitoneal injection over a 7-day period. In the control group, DMSO was used instead of erastin.At 15 days, the mice were sacrificed and endometriotic lesions were collected.

e0154605. doi: 10.1371/journal.pone.0154605. PMID: 27171435; PMCID: PMC4865238.

体内研究（动物模型）：

动物模型（Animal Model）：HT-29 tumor bearing SCID mice

实验方法（Assay）：Briefly, 2×106viable HT-29 cells in 100 μL of growth medium (per mouse) were subcutaneously inoculated, and mice bearing ~100 mm3tumors were randomly divided into three groups with 10 mice per group.Mice were treated daily with 10 or 30 mg/kg body weight of erastin (intraperitoneal injection, for 4 weeks) or vehicle control (Saline).

价格（元）

Erastin爱拉斯汀（铁死亡激活剂）

Erastin爱拉斯汀（铁死亡激活剂）

1350

2350

6350

溶剂体积

浓度

体内研究（动物模型）：

动物模型（Animal Model）：Endometriosis mouse model

实验方法（Assay）：Seven-to-8-week-old C57BL/6 female mice were obtained and 17-β-estradiol-3-benzoate (30µg/kg) was administered to each mouse every day for 3 days. We removed uterine horns from the donor mice and added them to saline. Endometrium was cut into 1mm2 fragments. The endometrial fragments from each uterine horn were suspended in 0.3ml saline and injected into the peritoneal cavities of recipient mice with an 18-gauge needle. At 8 days (5 days after the operation), endometrial-like lesions were established, and they were randomly divided into two groups (each group contained 12 mice).In the experimental group, each mouse received erastin (20mg/kg/day) by intraperitoneal injection over a 7-day period. In the control group, DMSO was used instead of erastin.At 15 days, the mice were sacrificed and endometriotic lesions were collected.

e0154605. doi: 10.1371/journal.pone.0154605. PMID: 27171435; PMCID: PMC4865238.

体内研究（动物模型）：

动物模型（Animal Model）：HT-29 tumor bearing SCID mice

实验方法（Assay）：Briefly, 2×106viable HT-29 cells in 100 μL of growth medium (per mouse) were subcutaneously inoculated, and mice bearing ~100 mm3tumors were randomly divided into three groups with 10 mice per group.Mice were treated daily with 10 or 30 mg/kg body weight of erastin (intraperitoneal injection, for 4 weeks) or vehicle control (Saline).

价格（元）

Erastin爱拉斯汀（铁死亡激活剂）

Erastin爱拉斯汀（铁死亡激活剂）

1350

2350

6350

溶剂体积

浓度

体内研究（动物模型）：

动物模型（Animal Model）：Endometriosis mouse model

实验方法（Assay）：Seven-to-8-week-old C57BL/6 female mice were obtained and 17-β-estradiol-3-benzoate (30µg/kg) was administered to each mouse every day for 3 days. We removed uterine horns from the donor mice and added them to saline. Endometrium was cut into 1mm2 fragments. The endometrial fragments from each uterine horn were suspended in 0.3ml saline and injected into the peritoneal cavities of recipient mice with an 18-gauge needle. At 8 days (5 days after the operation), endometrial-like lesions were established, and they were randomly divided into two groups (each group contained 12 mice).In the experimental group, each mouse received erastin (20mg/kg/day) by intraperitoneal injection over a 7-day period. In the control group, DMSO was used instead of erastin.At 15 days, the mice were sacrificed and endometriotic lesions were collected.

e0154605. doi: 10.1371/journal.pone.0154605. PMID: 27171435; PMCID: PMC4865238.

体内研究（动物模型）：

动物模型（Animal Model）：HT-29 tumor bearing SCID mice

实验方法（Assay）：Briefly, 2×106viable HT-29 cells in 100 μL of growth medium (per mouse) were subcutaneously inoculated, and mice bearing ~100 mm3tumors were randomly divided into three groups with 10 mice per group.Mice were treated daily with 10 or 30 mg/kg body weight of erastin (intraperitoneal injection, for 4 weeks) or vehicle control (Saline).

价格（元）

Erastin爱拉斯汀（铁死亡激活剂）

Erastin爱拉斯汀（铁死亡激活剂）

1350

2350

6350

溶剂体积

浓度

体内研究（动物模型）：

动物模型（Animal Model）：Endometriosis mouse model

实验方法（Assay）：Seven-to-8-week-old C57BL/6 female mice were obtained and 17-β-estradiol-3-benzoate (30µg/kg) was administered to each mouse every day for 3 days. We removed uterine horns from the donor mice and added them to saline. Endometrium was cut into 1mm2 fragments. The endometrial fragments from each uterine horn were suspended in 0.3ml saline and injected into the peritoneal cavities of recipient mice with an 18-gauge needle. At 8 days (5 days after the operation), endometrial-like lesions were established, and they were randomly divided into two groups (each group contained 12 mice).In the experimental group, each mouse received erastin (20mg/kg/day) by intraperitoneal injection over a 7-day period. In the control group, DMSO was used instead of erastin.At 15 days, the mice were sacrificed and endometriotic lesions were collected.

e0154605. doi: 10.1371/journal.pone.0154605. PMID: 27171435; PMCID: PMC4865238.

体内研究（动物模型）：

动物模型（Animal Model）：HT-29 tumor bearing SCID mice

实验方法（Assay）：Briefly, 2×106viable HT-29 cells in 100 μL of growth medium (per mouse) were subcutaneously inoculated, and mice bearing ~100 mm3tumors were randomly divided into three groups with 10 mice per group.Mice were treated daily with 10 or 30 mg/kg body weight of erastin (intraperitoneal injection, for 4 weeks) or vehicle control (Saline).