产品详情

别名

　Pycard、甲基化诱导沉默的靶点1、TMS1、Caspase Recruitment Domain-containing Protein 5、

　细胞凋亡相关Speck样蛋白 CARD、CARD5

产品类型

　多克隆抗体

免疫动物/宿主

　兔

免疫原/抗原

　对应于 N 末端人 Asc 的氨基酸合成肽.

应用

　免疫细胞化学（1：200）
　免疫组织化学（1：500；paraffin sections）
　免疫沉淀（1：200）
　Western Blot（1：1000）
　功能应用（见参考文献 [1]）

交叉反应性

　人、小鼠

特异性

　识别人和小鼠 Asc.

纯度

　表位亲和纯化

浓度

　1 mg/mL

配方

　液体，溶解在含有 10％ 甘油和 0.02％ 叠氮钠的 PBS 中

运输

　干冰

短时间储存

　+4°C

长时间储存

　-20°C

[1]

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini,et al.; Immunity 20, 319 (2004)

[2]

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1beta in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008)

[3]

Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF: L. Kolly, et al.; J. Immunol. 183, 4003 (2009)

[4]

Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinatedinflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255  (2012)

[5]

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.;  Nature 493, 674 (2013)

[6]

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation: J.K. Dowling, et al.; J. Biol. Chem. 289, 6429 (2014)

[7]

Localization and functionality of the inflammasome in neutrophils: M. Bakele, et al.; J. Biol. Chem. 289, 5320 (2014)

[8]

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014)

[9]

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014)

[10]

Aging-associated TNF production primes inflammasome activation and Nlrp3-related metabolic disturbances: F. Bauernfeind, et al.; J. Immunol. 197, 2900 (2016)

[11]

An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline: H. Wolfe; Thesis Univ. Dublin, Trinity College Dep. of Physiol. (2018)