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The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1. Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S. Sci Rep. 2017 Oct 12;7(1):13086.
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A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy. Yu Guan, Daisuke Nakano, Yifan Zhang, Lei Li, Wenhua Liu, Motohiro Nishida, Takashige Kuwabara, Asahiro Morishita, Hirofumi Hitomi, Kiyoshi Mori, Masashi Mukoyama, Tsutomu Masaki, Katsuya Hirano, Akira Nishiyama. Journal of Pharmacological Sciences, Available online 14, Sep 2017.
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Rosuvastatin pretreatment suppresses distant organ injury following unilateral renal ischemia-reperfusion in hypertensive Dahl salt-sensitive rats. Kanno M, Nakayama M, Zhu WJ, Hayashi Y, Kazama JJ. Nephrology (Carlton). 2017 Sep 22.
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Podocan Is Expressed in Blood and Adipose Tissue and Correlates Negatively With the Induction of Diabetic Nephropathy ? Yasunori Nio, Mitsugi Okawara, Shoki Okuda, Takanori Matsuo, Naoki Furuyama. Journal of the Endocrine Society, Vol.1, Issue 7, Jul 2017, Pages 772-786,
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LXR, PPARγ, and PPARδ Agonists Are Not Sufficient to Demonstrate Therapeutic Potential against Mouse Model of Systemic Lupus Erythematosus. Toyota Tatebe N, Sunahori Watanabe K, Zeggar S, Hiramatsu S, Yan M, Katsuyama T, Katsuyama E, Watanabe H, Sada K, Wada J. Open Journal of Rheumatology and Autoimmune Diseases, 2017, 7, 128-136
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Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice. Zhao L, Wang H, Xie J, Chen Z, Li X, Niu J. BMC Biotechnol. 2017 Jul 4;17(1):58.
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Renoprotective effect of a novel selective PPARα modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway. Maki T, Maeda Y, Sonoda N, Makimura H, Kimura S, Maeno S, Takayanagi R, Inoguchi T. Metabolism. 2017 Jun;71:33-45.
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Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes. Gao Z, Chen X, Zhu K, Zeng P, Ding G. Biomed Res Int. 2017;2017:2484303.
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Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms. He P, Kawamura H, Takemoto M, Maezawa Y, Ishikawa T, Ishibashi R, Sakamoto K, Shoji M, Hattori A, Yamaga M, Ide S, Ide K, Hayashi A, Tokuyama H, Kobayashi K, Yokote K. J Nephrol. 2016 Dec 22.
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Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppresses renal damage in KKAy/Ta mice, obese and type 2 diabetic animals. Ishibashi Y, Matsui T, Yamagishi SI. Diab Vasc Dis Res. 2016 Jul 12.
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Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice. Wang Z, Hwang SH, Lee SY, Lim SS. Nutr Res Pract. 2016 Jun;10(3):282-7.
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Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis. Ebihara S, Tajima H, Ono M. Arthritis Res Ther. 2016 Jun 14;18(1):139.
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A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K. Sci Rep. 2016 May 16;6:25955.
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Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6-producing lung carcinoma cells. Noguchi-Sasaki M, Sasaki Y, Shimonaka Y, Mori K, Fujimoto-Ouchi K. BMC Cancer. 2016 Apr 11;16:270.
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Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice. Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y. PLoS One. 2016 Mar 24;11(3):e0152191.
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Chronic Administration of Visfatin Ameliorated Diabetic Nephropathy in Type 2 Diabetic Mice. Kang YS, Lee MH, Song HK, Kim JE, Ghee JY, Cha JJ, Lee JE, Kim HW, Han JY, Cha DR. Kidney Blood Press Res. 2016;41(3):311-24.
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Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney. Morita T, Nakano D, Kitada K, Morimoto S, Ichihara A, Hitomi H, Kobori H, Shiojima I, Nishiyama A. Eur J Pharmacol. Vol.756, p85-91, Jun 2015.
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Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney. Morita T, Nakano D, Kitada K, Morimoto S, Ichihara A, Hitomi H, Kobori H, Shiojima I, Nishiyama A. Eur J Pharmacol. Mar 2015.
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C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice. Kimura T, Nojiri T, Hosoda H, Ishikane S, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K. J Surg Res. Vol.194(2), p631-7, Apr 2015.
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Myocardial infarction accelerates glomerular injury and microalbuminuria in diabetic rats via local hemodynamics and immunity. Dong Z, Gong K, Huang D, Zhu W, Sun W, Zhang Y, Xin P, Shen Y, Wu P, Li J, Lu Z, Zhang X, Wei M. Int J Cardiol.Vol.179, p397-408, Jan 2015.
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Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet. Min HS., Kim JE., Lee MH., Song HK., Lee MJ., Lee JE., Kim HW., Cha JJ., Hyun YY., Han JY., Cha DR., Kang YS. Kidney Research and Clinical Practice, 2014.
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Ameliorates the Progression of Type 2 Diabetic Nephropathy by Exerting Antioxidative Effects. Ishizawa K., Izawa-Ishizawa Y., Yamano N., Urushihara M., Sakurada T., Imanishi M., Fujii S., Nuno A., Miyamoto L., Kihira Y., Ikeda Y., Kagami S., Kobori H., Tamaki T. PLOS one, 2014
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T olvaptan delays the onset of end-stage renal disease in a polycystic kidney disease model by suppressing the increases in kidney volume and renal injury. Aihara M., Fujiki H., Mizuguchi H., Hattori K., Ohmoto K., Ishikawa M., Nagano K. and Yamamura Y. JPET, Feb 2014.
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Local Mineralocorticoid Receptor Activation and the Role of Rac1 in Obesity-Related Diabetic Kidney Disease. Yoshida S., Ishizawa K., Ayuzawa N., Ueda K., Takeuchi M., Kawarazaki W., Fujita T., Nagase M. Nephron Exp Nephrol, Vol.126, p16-24, 2014.
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Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. Yoshida S., Ishizawa K., Ayuzawa N., Ueda K., Takeuchi M., Kawarazaki W., Fujita T., Nagase M. Clinical and Experimental Nephrology, Oct 2013.
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Fibroblast Growth Factor 21 Improves Insulin Resistance and Ameliorates Renal Injury in db/db Mice. Kim HW., Lee JE., Cha JJ., Hyun YY., Kim JE., Lee MH., Song HK., Nam DH., Han JY., Han SY., Han KH., Kang YS. and Cha DR. Endocrinology, Vol.154(9), Sep 2013.
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Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Zheng J., Inoguchi T., Sasaki S., Maeda Y., McCarty MF., Fujii M., Ikeda N., Kobayashi K., Sonoda N., Takayanagi R. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, Vol.304, R110-120, Jun 2013.
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Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Zheng J., Inoguchi T., Sasaki S., Maeda Y., McCarty MF., Fujii M., Ikeda N., Kobayashi K., Sonoda N., Takayanagi R. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, Vol.304, R110-120, Jun 2013.
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Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice. J.E.Kim, M.H.Lee, D.H.Nam, H.K.Song, Y.S.Kang, J.E.Lee, H.W.Kim, J.J.Cha, Y.Y.Hyun, S.Y.Han, K.H.Han, J.Y.Han, D.R.Cha. PLOS one 2013.
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Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Zheng J, InoguchiT, SasakiS, MaedaY, McCarty M F, Fujii M, Ikeda N, Kobayashi K, Sonoda N and Takayanagi R. AJP – Regu Physiol,Vo.304(2),p110-120 Jan 2013.
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Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. J.Zheng, T.Inoguchi, S.Sasaki, Y.Maeda, M.F.McCarty, M.Fujii, N.Ikeda, K.Kobayashi, N.Sonoda, R.Takayanagi. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, Vol.304, Jan 2013.
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Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan. Lei B, Nakano D, Fan Y-Y, Kitada K, Hitomi H, Kobori H, Mori H, Masaki T and Nishiyama A. J Pharmacol Sci,Vol.119(2), p131-138,Jun 2012.
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Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice. Nakano D, Lei B, Kitada K, Hitomi H, Kobori H, Mori H, Deguchi K, Masaki T, Minamino T and Nishiyama A. Am J Hypertens, Vol.25(3), p354-358, Mar 2012.
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Blockade of Cannabinoid Receptor 1 Improves Insulin Resistance, Lipid Metabolism, and Diabetic Nephropathy in db/db Mice. D. H. Nam., M. H. Lee., J. E. Kim., H. K. Song., Y. S. Kang., J. E. Lee., H. W. Kim., J. J. Cha., Y. Y. Hyun., S. H. Kim., S. Y. Han., K. H. Han, J. Y. Han and Dae Ryong Cha. Endocrinology, Vol.153, No.3, p1387-1396, Mar 2012.
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An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice. M. Koshizaka., M. Takemoto., S. Sato., H. Tokuyama., M. Fujimoto., E. Okabe., R. Ishibashi., T. Ishikawa., Y. Tsurutani., S. Onishi., M. Mezawa., P. He., S. Honjo., S. Ueda., Y. Saito and K. Yokote. Experimental Diabetes Research, Vol.2012.
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Advanced-glycation-end-product-cholesterol-aggregated-protein accelerates the proliferation of mesangial cells mediated by transforming-growth-factor-beta 1 receptors and the ERK-MAPK pathway. Hirasawa Y, Sakai T, Ito M, Yoshimura H, Feng Y, Nagamatsu T. European Journal of Pharmacology, Vol.672(1-3), p159-168, Dec 2011.
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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. S. Sekiya., A. Suzuki. Nature 475,390-393(2011)
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Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice. Y. S. Kang., M. H. Lee., H. K. Song., Y. Y. Hyun., J. J. Cha., G. J. Ko., S. H. Kim., J. E. Lee., J. Y. Han. and D. R. Cha. Nephrol. Dial. Transplant. (2011) 26 (4): 1194-1204.
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Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice. N. N.-Alvarez., A. S.-Gutierrez., Y. Chen., J. C.-Corbalan., W. Hassan., S. Kobayashi., Y. Kondo., M. Iwamuro., K. Yamamoto., E. Kondo., N. Tanaka., I. J. Fox., N. Kobayashi. Journal of Hepatology Vol. 52(2), p211-219, 2010.
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CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kang,Y.S.,Lee,M.H.,Song,H.K.,Ko,G.J.,Kwon,O.S.,Lim,T.K.,Kim,S.H.,Han,S.Y.,Hyun,K. Kidney International, Vol.78, p883-894, November(1), 2010
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Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice. Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y, Ohishi M, Katsuya T, Hoshida Y, Aozasa K, Ogihara T and Nishimoto N. AJP – Renal Physiol, Vol.297(3), p679-684, Sep 2009.
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Elevated Urinary Cr Loss Induces a Reduction in Renal Cr Concentration and the Negative Cr Balance in Streptozotocin-Induced Diabetic Mice. MITA Y, ISHIHARA K, ISHIGURO M, TAKEDA M, HATTORI R, MURAKAMI K, YAMADA A, YASUMOTO K. Journal of Nutritional Science and Vitaminology,Vol. 54(4), p303-308, 2008.
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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y and Fujita T. NTURE MEDFICINE, Vol.14(12), p1370-1376, Dec 2008.
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Rubratoxin B induces interleukin-6 secretion in mouse white Adipose tissues and 3T3-L1 adipocytes. Keiko Iwashita,Hitoshi Nagashima. Toxicology Letters, Vol.182, p79-83, 2008.
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Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells. Kato,H., Ishida,J., Nagano,K., Honjo,K., Sugaya,T., Takeda,N., Sugiyama,F., Yagami,K., Fujita,T., Nangaku,M., and Fukamizu, A. Lab Invest., Vol.88(7), p731-9, 2008.
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Differentiation of mouse and human embryonic stem cells into hepatic lineages. Shiraki,N., Umeda,K., Sakashita,N., Takeya,M., Kume,K., and Kume, S. Genes to Cells, Vol.13, p731-746, 2008.
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Effect of Lactobacillus jonsonii La1 on immune function and serum albumin in aged and malnourished aged mice. Kaburagi, T., Yamano, T., Fukushima, Y, Yoshino, H., Mito, N., and Sato, K. Nutrition Vol.24, p342-350, 2007.
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Differentiation of mouse embryonic stem cells to hepatocyto-like cells by co-culture with human liver nonparenchymal cell lines. Soto-Gutierrez, A., Navarro-Alvarez, N., Zhao, D., Rivas, J.D., Rivas-Carillo, J.D., Lebkowski, J., Tanaka, N., Fox, I.J., and Kobayashi, N. Nature Protocols. Electronic Edition Vol.2, p347-356, 2007.
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Construction and transplantation of an engineered hepatic tissue using a polyaminourethane-coated nonwoven polytetrafluoroethylene fabric. Soto-Gutierrez, A., Navarro-Alvarez, N., Rivas, J.D., Tanaka, K., Chen, Y., Misawa, H., Okitsu, T., Noguchi, H., Tanaka, N., and Kobayashi, N. Transplantation, Vol.83, p129-137, 2007.
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Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Fujii, M., Inoguchi, T., Maeda, Y., Sasaki, S., Sawada, F., saito, R., Kobayashi, K., Sumitomo, H., and Takayanagi, R. Kidney International, Vol.72, p473-480, 2007.
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Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system. Tsutsui, M., Ogawa, S., Inada, Y., Tomioka, E., Kamiyoshi, A., Tanaka, S., Kishida, S., Nishiyama, M., Murakami, M., Kuroda, J., Hashikura, Y., Miyagawa, S., satoh, F., shibata, N., and Tagawa, Y. Drug Metabolism and Disposition, Vol.34, p696-701, 2006.
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Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Kosugi, T., Yuzawa, Y., sato, W., Kawai, H., Matsuo, S.,Takei,Y.,Muramatsu,T., and Kadomatsu,K. Am J Pathology Vol.168, p9-19, 2006.
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Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice. Mita, Y., Ishihara, K., Fukuchi, Y., Fukuya, Y., and Yasumoto, K. Biological Trace Element Research, Vol.105, p229-248, 2005.
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6-Methylsulfinylhexyl Isothiocyanate, an Antioxidant Derived from Wasabia japonica MATUM, Ameliorates Diabetic Nephropathy in Type 2 Diabetic Mice. FUKUCHI Y, KATO Y, OKUNISHI I, MATSUTANI Y, OSAWA T, NAITO M. Food Science and Technology Research, Vol.10(3), p290-295, 2004.
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