Arbutin 熊果苷


描述

Arbutin 熊果苷

产品标签

Arbutin 熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;CAS:497-76-7;

产品信息

产品名称 产品编号 规格             价格(元)   
Arbutin 熊果苷        MZ95031-5G       5g 280
Arbutin 熊果苷 MZ95031-25G 25g 840

产品描述

熊果苷 (Arbutin,CAS:497-76-7),又称为β-熊果苷(β-Arbutin),p-熊果苷(p-Arbutin),是一种糖苷,用于传统中药中的一种糖基化氢醌(即对苯二酚)。熊果苷是一种酪氨酸酶抑制剂,从而抑制黑色素的生成。

产品特性

1)   CAS NO:497-76-7 

2)   化学名:(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6- (4-hydroxyphenoxy)oxane-3,4,5-triol

3)  同义名:p-Arbutin, β-Arbutin, Hydroquinone β-D-glucopyranoside, 4-Hydroxyphenyl-β-D-glucopyranoside, Uva, Ursi; β-熊果苷,熊果素,熊果甙,熊果酚甙,熊葡萄叶素,对-羟基苯-β-D-吡喃葡萄糖苷;

4)   分子式:C12H16O7

5)   分子量:272.25

6)   纯度:≥99.5%

7)   外观:白色结晶或粉末

8)   溶解性:溶于DMSO(50mg/ml),H2O(50mg/ml),几乎不溶于乙醇

9)   化学结构图:

保存与运输方法

保存:2-8ºC干燥保存,2年有效;-20ºC干燥保存,3年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

相关产品

货号 名称 规格           
MZ95031-5G       Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)     25KU

 

 

 

Arbutin 熊果苷


描述

Arbutin 熊果苷

产品标签

Arbutin 熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;CAS:497-76-7;

产品信息

产品名称 产品编号 规格             价格(元)   
Arbutin 熊果苷        MZ95031-5G       5g 280
Arbutin 熊果苷 MZ95031-25G 25g 840

产品描述

熊果苷 (Arbutin,CAS:497-76-7),又称为β-熊果苷(β-Arbutin),p-熊果苷(p-Arbutin),是一种糖苷,用于传统中药中的一种糖基化氢醌(即对苯二酚)。熊果苷是一种酪氨酸酶抑制剂,从而抑制黑色素的生成。

产品特性

1)   CAS NO:497-76-7 

2)   化学名:(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6- (4-hydroxyphenoxy)oxane-3,4,5-triol

3)  同义名:p-Arbutin, β-Arbutin, Hydroquinone β-D-glucopyranoside, 4-Hydroxyphenyl-β-D-glucopyranoside, Uva, Ursi; β-熊果苷,熊果素,熊果甙,熊果酚甙,熊葡萄叶素,对-羟基苯-β-D-吡喃葡萄糖苷;

4)   分子式:C12H16O7

5)   分子量:272.25

6)   纯度:≥99.5%

7)   外观:白色结晶或粉末

8)   溶解性:溶于DMSO(50mg/ml),H2O(50mg/ml),几乎不溶于乙醇

9)   化学结构图:

保存与运输方法

保存:2-8ºC干燥保存,2年有效;-20ºC干燥保存,3年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

相关产品

货号 名称 规格           
MZ95031-5G       Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)     25KU

 

 

 

alpha-Arbutin alpha-熊果苷


描述

alpha-Arbutin alpha-熊果苷

产品标签

α-Arbutin α-熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;CAS:84380-01-8;

产品信息

产品名称 产品编号 规格            价格(元)    
alpha-Arbutin alpha-熊果苷    MZ95032-1G      1g 228
alpha-Arbutin alpha-熊果苷 MZ95032-5G 5g 678

产品描述

alpha-熊果苷 (alpha-Arbutin,CAS:84380-01-8),又称为α-熊果苷(α-Arbutin),是一种糖苷,用于传统中药中的一种糖基化氢醌(即对苯二酚)。alpha-熊果苷是一种酪氨酸酶抑制剂,从而抑制黑色素的生成,可用于化妆品中作为美白剂。

产品特性

1)   CAS NO:84380-01-8

2)  英文同义名:α-Arbutin, alpha-Arbutoside, 4-hydroxyphenyl alpha-glucopyranoside, 4-Hydroxyphenyl-α-D- glucopyranoside; 4-Hydroquinone-alpha-D-glucopyranoside;

3)   中文同义名:α-熊果苷,α-熊果甙,对苯二酚-α-D-葡萄糖苷,4-羟基苯-α-D-吡喃葡萄糖苷;

4)   分子式:C12H16O7

5)   分子量:272.25

6)   纯度:≥99%

7)   外观:白色结晶或粉末

8)   溶解性:溶于DMSO(50mg/ml)

9)   化学结构图:

保存与运输方法

保存:2-8ºC干燥保存,1年有效;-20ºC干燥保存,2年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

相关产品

货号 名称 规格            
MZ95031-5G     Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)    25KU

 

 

 

alpha-Arbutin alpha-熊果苷


描述

alpha-Arbutin alpha-熊果苷

产品标签

α-Arbutin α-熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;CAS:84380-01-8;

产品信息

产品名称 产品编号 规格            价格(元)    
alpha-Arbutin alpha-熊果苷    MZ95032-1G      1g 228
alpha-Arbutin alpha-熊果苷 MZ95032-5G 5g 678

产品描述

alpha-熊果苷 (alpha-Arbutin,CAS:84380-01-8),又称为α-熊果苷(α-Arbutin),是一种糖苷,用于传统中药中的一种糖基化氢醌(即对苯二酚)。alpha-熊果苷是一种酪氨酸酶抑制剂,从而抑制黑色素的生成,可用于化妆品中作为美白剂。

产品特性

1)   CAS NO:84380-01-8

2)  英文同义名:α-Arbutin, alpha-Arbutoside, 4-hydroxyphenyl alpha-glucopyranoside, 4-Hydroxyphenyl-α-D- glucopyranoside; 4-Hydroquinone-alpha-D-glucopyranoside;

3)   中文同义名:α-熊果苷,α-熊果甙,对苯二酚-α-D-葡萄糖苷,4-羟基苯-α-D-吡喃葡萄糖苷;

4)   分子式:C12H16O7

5)   分子量:272.25

6)   纯度:≥99%

7)   外观:白色结晶或粉末

8)   溶解性:溶于DMSO(50mg/ml)

9)   化学结构图:

保存与运输方法

保存:2-8ºC干燥保存,1年有效;-20ºC干燥保存,2年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

相关产品

货号 名称 规格            
MZ95031-5G     Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)    25KU

 

 

 

Deoxyarbutin 脱氧熊果苷


描述

Deoxyarbutin 脱氧熊果苷

产品标签

Deoxyarbutin 脱氧熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;Polyphenol Oxidase 蘑菇多酚氧化酶;CAS:53936-56-4;

产品信息

产品名称 产品编号 规格              价格(元)    
Deoxyarbutin 脱氧熊果苷      MZ95033-1G         1g 360
Deoxyarbutin 脱氧熊果苷 MZ95033-5G 5g 780

产品描述

脱氧熊果苷(Deoxyarbutin,CAS:53936-56-4)是一种有效且可逆的酪氨酸酶抑制剂(IC50=50nM)。能抑制黑色素合成,引起明显和长期的皮肤增白效果。

产品特性

1)   CAS NO:53936-56-4

2)   化学名:4-(Oxan-2-yloxy)phenol

3)   分子式:C11H14O3

4)   分子量:194.23

5)   纯度:≥99%

6)   外观:白色或类白色粉末

7)   溶解性:溶于DMSO(100mM)、乙醇(100mM)、不溶于水

8)   化学结构图:

保存与运输方法

保存:-20ºC干燥保存,至少2年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

配制储存液

         质量

溶剂体积

浓度

1mg                      5mg                   10mg                  100mg              
1mM               5.1485 mL 25.7427 mL 51.4854 mL 514.8535 mL
5mM 1.0297 mL 5.1485 mL 10.2971 mL 102.9707 mL
10mM 0.5149 mL 2.5743 mL 5.1485 mL 51.4854 mL
50mM 0.1030 mL 0.5149 mL 1.0297 mL 10.2971 mL

使用方法【源自文献,仅作参考】

文献1,Boissy RE et al.DeoxyArbutin: A novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.Exp Dermatol. 2005 Aug;14(8):601-8. PMID: 16026582

体内研究(动物):

动物模型(Animal Model):Hairless pigmented (black) guinea pig models

药物配制(Preparation):dA (DeoxyArbutin) was prepared in I base cream consisting of water (25%), 0.2M triethanolamine hydrochloride (44.5%), glycerin (3.75%), Parson MCX (7.5%), cutina GMS (2.5%), and tegin 90 (2.5%).

实验方法(Assay):For experiments comparing skin lightening effects of test compounds, skin was treated daily for 9 weeks with dA, Hydroquinone (HQ), kojic acid and arbutin (3%) in I base cream. Ten animals were in each treatment group, and three independent experiments were performed. Skin lightness was measured at baseline and then weekly with a colorimeter.

实验结果(Results):Both dA and HQ resulted in skin lightening during the initial 3 weeks of treatment, the extent of dA-induced skin lightening plateaued while the HQ-treated skin darkened and returned to the pretreatment value. The dA treated sites showed no signs of skin irritation. In contrast, HQ treated skin showed signs of irritation that resulted in irregular darkening, beginning at 3 weeks of treatment. In contrast, kojic acid, and arbutin were not significantly different from the vehicle control.

文献2,Chawla S et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.. Br J Dermatol. 2008 Dec;159(6):1267-74. PMID:18811684

体内研究(细胞):

细胞类型(Cell type):Human melanocytes

药物配制(Preparation):All compounds (dA, dF, fdA, tdA and HQ) were dissolved in sterile DMSO. Stock solutions of compounds were prepared and protected from light at -20℃until use. At time of use, compounds were further diluted in growth medium to produce the final required concentration. Compounds were tested at the appropriate concentration range (1-100μM) in triplicate in order to calculate LD50values.

实验方法(Assay):Melanocytes were seeded at 1-3×105cells and allowed to grow for 48h before treatment. Cultured were treated daily with fresh growth media containing test compound for 5 days. On the sixth day, cells were detached and counted.

实验结果(Results):A concentration-dependent decrease in the cell number of both was observed for all inhibitors (dA, dF, fdA, tdA and HQ). LD50concentrations of dA and its derivatives are listed below.

LD50(dark melanocytes) LD50(light melanocytes)
dA (deoxyarbutin) 57.7±1.5 104.7±1.0
tdA (thideoxyarbutin) 48.0±2.0 87.8±2.5
fdA (fluorodeoxyarbutin) 89.1±0.7 106±1.5

相关产品

货号 名称 规格              
MZ95031-5G       Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)    25KU

 

 

 

Deoxyarbutin 脱氧熊果苷


描述

Deoxyarbutin 脱氧熊果苷

产品标签

Deoxyarbutin 脱氧熊果苷;β-Arbutin β-熊果苷;Tyrosinase inhibitor 酪氨酸酶抑制剂;Melanin production inhibitor 黑色素生成抑制剂;Polyphenol Oxidase 蘑菇多酚氧化酶;CAS:53936-56-4;

产品信息

产品名称 产品编号 规格              价格(元)    
Deoxyarbutin 脱氧熊果苷      MZ95033-1G         1g 360
Deoxyarbutin 脱氧熊果苷 MZ95033-5G 5g 780

产品描述

脱氧熊果苷(Deoxyarbutin,CAS:53936-56-4)是一种有效且可逆的酪氨酸酶抑制剂(IC50=50nM)。能抑制黑色素合成,引起明显和长期的皮肤增白效果。

产品特性

1)   CAS NO:53936-56-4

2)   化学名:4-(Oxan-2-yloxy)phenol

3)   分子式:C11H14O3

4)   分子量:194.23

5)   纯度:≥99%

6)   外观:白色或类白色粉末

7)   溶解性:溶于DMSO(100mM)、乙醇(100mM)、不溶于水

8)   化学结构图:

保存与运输方法

保存:-20ºC干燥保存,至少2年有效。

运输:室温运输

注意事项

1)   本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。

2)   为了您的安全和健康,请穿实验服并戴一次性手套操作。

配制储存液

         质量

溶剂体积

浓度

1mg                      5mg                   10mg                  100mg              
1mM               5.1485 mL 25.7427 mL 51.4854 mL 514.8535 mL
5mM 1.0297 mL 5.1485 mL 10.2971 mL 102.9707 mL
10mM 0.5149 mL 2.5743 mL 5.1485 mL 51.4854 mL
50mM 0.1030 mL 0.5149 mL 1.0297 mL 10.2971 mL

使用方法【源自文献,仅作参考】

文献1,Boissy RE et al.DeoxyArbutin: A novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.Exp Dermatol. 2005 Aug;14(8):601-8. PMID: 16026582

体内研究(动物):

动物模型(Animal Model):Hairless pigmented (black) guinea pig models

药物配制(Preparation):dA (DeoxyArbutin) was prepared in I base cream consisting of water (25%), 0.2M triethanolamine hydrochloride (44.5%), glycerin (3.75%), Parson MCX (7.5%), cutina GMS (2.5%), and tegin 90 (2.5%).

实验方法(Assay):For experiments comparing skin lightening effects of test compounds, skin was treated daily for 9 weeks with dA, Hydroquinone (HQ), kojic acid and arbutin (3%) in I base cream. Ten animals were in each treatment group, and three independent experiments were performed. Skin lightness was measured at baseline and then weekly with a colorimeter.

实验结果(Results):Both dA and HQ resulted in skin lightening during the initial 3 weeks of treatment, the extent of dA-induced skin lightening plateaued while the HQ-treated skin darkened and returned to the pretreatment value. The dA treated sites showed no signs of skin irritation. In contrast, HQ treated skin showed signs of irritation that resulted in irregular darkening, beginning at 3 weeks of treatment. In contrast, kojic acid, and arbutin were not significantly different from the vehicle control.

文献2,Chawla S et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.. Br J Dermatol. 2008 Dec;159(6):1267-74. PMID:18811684

体内研究(细胞):

细胞类型(Cell type):Human melanocytes

药物配制(Preparation):All compounds (dA, dF, fdA, tdA and HQ) were dissolved in sterile DMSO. Stock solutions of compounds were prepared and protected from light at -20℃until use. At time of use, compounds were further diluted in growth medium to produce the final required concentration. Compounds were tested at the appropriate concentration range (1-100μM) in triplicate in order to calculate LD50values.

实验方法(Assay):Melanocytes were seeded at 1-3×105cells and allowed to grow for 48h before treatment. Cultured were treated daily with fresh growth media containing test compound for 5 days. On the sixth day, cells were detached and counted.

实验结果(Results):A concentration-dependent decrease in the cell number of both was observed for all inhibitors (dA, dF, fdA, tdA and HQ). LD50concentrations of dA and its derivatives are listed below.

  LD50(dark melanocytes) LD50(light melanocytes)
dA (deoxyarbutin) 57.7±1.5 104.7±1.0
tdA (thideoxyarbutin) 48.0±2.0 87.8±2.5
fdA (fluorodeoxyarbutin) 89.1±0.7 106±1.5

相关产品

货号 名称 规格              
MZ95031-5G       Arbutin 熊果苷 5g
MZ95032-1G alpha-Arbutin alpha-熊果苷 1g
MZ95033-1G Deoxyarbutin 脱氧熊果苷 1g
MP0507-25KU Polyphenol Oxidase (Tyrosinase) 多酚氧化酶(酪氨酸酶)    25KU