Harlan 他莫昔芬饮食Tamoxifen diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Tamoxifen diets

Diets with tamoxifen activate CreER

Several references cite use of tamoxifen-containing diets for models with Cre under the control of a mutated estrogen receptor. Envigo Teklad diets makes a variety of tamoxifen-containing diets customized to meet your research needs. We also make a variety of doxycycline-containing diets for tet regulated systems. If you have any questions, don’t hesitate to consult a nutritionist.

Teklad stocks tamoxifen and tamoxifen citrate

Tamoxifen is added to the diet as a tamoxifen-sucrose mixture. Users are encouraged to use the stocked supply. However, Teklad will continue to work with customer prepared mixes. If you choose this option, please consult a nutritionist for additional information about preparing and sending the mixture.

含他莫昔芬的饮食可激活 CreER

一些参考文献引用了在突变雌激素受体控制下的 Cre 模型使用含他莫昔芬的饮食。 Envigo Teklad 饮食可定制各种含他莫昔芬的饮食，以满足您的研究需求。我们还为 tet 调节系统制作各种含有强力霉素的饮食。如果您有任何疑问，请随时咨询营养师。

Teklad 库存他莫昔芬和他莫昔芬柠檬酸盐

他莫昔芬作为他莫昔芬-蔗糖混合物添加到饮食中。鼓励用户使用库存供应。但是，Teklad 将继续使用客户准备的混合物。如果您选择此选项，请咨询营养师以获取有关准备和发送混合物的更多信息。

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上海金畔生物科技有限公司

Teklad offers diet with USP grade tamoxifen and tamoxifen citrate

Tamoxifen mg per kg diet	Daily tamoxifen mg per kg body weight¹	Diet code (Teklad supplied tamoxifen)	Diet code (Teklad supplied tamoxifen)
		Natural colored	Red
250	40	TD.130855	TD.130856
500	80	TD.130857	TD.130858
400 citrate²	40	TD.130859	TD.130860 ³

¹ Assumes 20-25 g body weight and three-four g intake
² Tamoxifen citrate is 66% tamoxifen
³ Referred to as TAM400/CreER in Europe (TD.55125 )

1 假设体重为 20-25 克，摄入量为 3-4 克
2 柠檬酸他莫昔芬是 66% 的他莫昔芬
3 在欧洲称为 TAM400/CreER (TD.55125 )

Please add 5-10 day lead time for irradiated diets; minimum 3 kg orders are required for stocked and customized items.

These diets all have tamoxifen premixed with ~five percent sucrose as a palatability enhancer; however, feed aversion may still occur. If intake is a problem, see below for advice.

Teklad Global 2016 — base diet in these examples — is only one of several minimal phytoestrogen diets Teklad produces. Consult a nutritionist about use of other base diets.

请为辐照饮食增加 5-10 天的交货时间；库存和定制商品至少需要 3 公斤订单。

这些饮食都含有预先混合了约 5% 蔗糖的他莫昔芬作为适口性增强剂；但是，仍然可能会出现饲料厌恶。如果摄入量有问题，请参阅下面的建议。

Teklad Global 2016（这些示例中的基础饮食）只是 Teklad 生产的几种最低植物雌激素饮食之一。咨询营养师关于其他基础饮食的使用。

Key planning information

Minimum order quantity is three kg, sufficient for feeding ~20 mice for one month
Store diet refrigerated and plan to use within six months
Typical lead time is two weeks (four weeks if irradiated)
Irradiation (optional) minimal dose of 20 kGy (Must be requested at time of order)

主要规划信息

最小起订量为 3 公斤，足够喂食约 20 只老鼠一个月
将饮食冷藏并计划在六个月内使用
典型的交货时间是两周（如果受到辐照，则为四个星期）
辐照（可选）最小剂量 20 kGy（必须在订购时提出要求）

Mice need time to adjust

Plan for:

Initial reduction in food intake and weight loss
Daily observation of animal tolerance — consult your IACUC for monitoring metrics
Intervene when necessary

Other researchers have the following advice

If intake seems to be a problem:

Determine if a lower dose is effective for your model by conducting a tamoxifen dose feeding trial
Gradually acclimate mice by mixing tamoxifen-containing pellets with regular feed pellets
Wet the food, then place in a dish inside the cage (requires daily replacement)
Feed tamoxifen diet on weekdays, regular diet on weekends
Alternate weeks (two weeks on tamoxifen diet, one week off) for longer treatments

Safe handling of tamoxifen diets

Tamoxifen is a selective estrogen receptor modulator (SERM) meaning it can repress actions of estrogen or have pro-estrogen effects
Usual dose for therapeutic effects in humans is 20 mg/day. Tamoxifen diets for rodents typically contain ~one to two mg/pellet
Accidental tamoxifen exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of tamoxifen containing diets.

Key points from literature

Length of treatment varies from one to two weeks^1,2,5,6,7,8 to one to two months^3,4,8
Pure tamoxifen1,5,8 and tamoxifen citrate^1,2,3,4,6,7 are both effective
Usual tamoxifen doses are ~40-80 mg per kg body weight per day
Typical inclusion for pure tamoxifen is 250 mg8 or 500 mg1,5 and for tamoxifen citrate is 400 mg per kg diet^1,2,3,4,6,7
Initial weight loss of ten % is reported^1,2,4,7,8, associated with reduced food intake²
Subsequent recovery of body weight after returning to regular diet may be compromised by gene inactivation^2,7

老鼠需要时间来调整
计划：

最初减少食物摄入和减轻体重
每日观察动物耐受性——咨询您的 IACUC 以了解监测指标
必要时进行干预
其他研究人员有以下建议
如果摄入量似乎有问题：

通过进行他莫昔芬剂量喂养试验确定较低剂量是否对您的模型有效
通过将含有他莫昔芬的颗粒与常规饲料颗粒混合来逐渐适应小鼠
弄湿食物，然后放在笼子里的盘子里（需要每天更换）
平日喂他莫昔芬饮食，周末规律饮食
隔周（他莫昔芬饮食两周，休息一周）进行更长时间的治疗
安全处理他莫昔芬饮食
他莫昔芬是一种选择性雌激素受体调节剂 (SERM)，这意味着它可以抑制雌激素的作用或具有促雌激素作用
人类治疗效果的常用剂量为 20 毫克/天。啮齿动物的他莫昔芬饮食通常含有约 1 至 2 毫克/粒
通过在处理饮食时使用实验室外套、手套和面罩等典型的实验室预防措施，可以最大限度地减少意外的他莫昔芬暴露。
应联系您的化学安全部门，以获取有关处理和处置含他莫昔芬饮食的其他机构特定指南。
文献要点
治疗时间从一到两周不等1,2,5,6,7,8 到一到两个月3,4,8
纯他莫昔芬1,5,8和他莫昔芬柠檬酸盐1,2,3,4,6,7均有效
通常的他莫昔芬剂量为每天每公斤体重约 40-80 毫克
纯他莫昔芬的典型含量为 250 mg8 或 500 mg1,5，柠檬酸他莫昔芬的含量为 400 mg/kg 饮食 1,2,3,4,6,7
据报道，最初体重减轻 10%1,2,4,7,8，这与食物摄入量减少有关 2
恢复正常饮食后体重的后续恢复可能会受到基因失活的影响2,7

Selected tamoxifen references 参考文献

¹ Andersson KB, Winer LH, Mork HK, Molkentin JD, Jaisser F. 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Res 19:715-725.

² Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci USA 107:16320-16324.

³ Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6:e21055.

⁴ Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M. 2007. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45:11-16.

⁵ Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15.

⁶ Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F. 2009. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. PCirc Res 106:559-572.

⁷ Miro-Murillo M, Elorza A, Soro-Arnaiz I, Albacete-Albacete L, Ordonez A, Balsa E, Vara-Vega A, Vazquez S, Fuertes E, Fernandez-Criado C, Landazuri MO, Aragones J. 2011. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS One 6:e22589.

⁸ Welle S, Burgess K, Thornton CA, Tawil R. 2009. Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab.Oct;297(4):E935-40.

Technical resources 技术文章

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图片仅供参考,请以实物为准。

若本网站没有及时更新，请大家谅解！
正文中列出的所有试剂只能用于测试或研究，不能作为”药品”，”食品”，”家庭用品”等使用。
我司所销售的化学试剂、原料等所有产品（包括但不限于抗生素类、蛋白质类、试剂盒类产品等）仅限用于科学研究用途，不得作用于人体。

Harlan 客户提供成分定制饲料Customer supplied ingredients

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 客户提供成分定制饲料Customer supplied ingredients

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Customer supplied ingredients

Customizing diets for all types of research needs

When your experiments require the addition or application of certain compounds to your animal research subject, you can consider adding your medications or compounds to your animal’s diet. Envigo has experience customizing diets for all types of research needs, and that includes introducing additives as a convenient way to medicate lab animals. Simply turn to one of our expert staff nutritionists to determine whether it is a viable option.

Medications or compounds supplied by your investigator are referred to as “customer supplied ingredients” or “customer reserves,” and they can be added to most diets. Generally, if the stability or activity of the compound is not compromised during manufacture or further processing such as irradiation, adding an ingredient can be a smart option for simplifying your feeding and medicating schedules. Also, the inclusion rate of any given compound is adjusted to suit your needs, and can be determined in consultation with our expert nutritional staff.

当您的实验需要在动物研究对象中添加或应用某些化合物时，您可以考虑将药物或化合物添加到动物的饮食中。 Envigo 拥有为所有类型的研究需求定制饮食的经验，其中包括引入添加剂作为对实验动物进行药物治疗的便捷方式。只需求助于我们的一位专业营养师来确定这是否是一个可行的选择。

您的研究人员提供的药物或化合物被称为“客户提供的成分”或“客户储备”，它们可以添加到大多数饮食中。一般来说，如果化合物的稳定性或活性在制造或进一步加工（如辐照）过程中没有受到影响，添加一种成分可能是简化您的喂养和用药计划的明智选择。此外，任何给定化合物的包含率都会根据您的需要进行调整，并且可以与我们的专业营养人员协商确定。

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Please use the customer supplied ingredients submission form if you require the addition or application of certain compounds to your animal research subject.

Some common customer supplied compounds include:

Cuprizone (also now stocked)
Tamoxifen (also now stocked: US, EU)
Purified fatty acids (DHA, EPA)
Curcumin
Rosiglitazone
Statins
Antibiotics
Valproate
Piroxicam
Berry powders
Bisphenol A (BPA, in diluted form)

When adding a compound to a diet, we will work with you to be sure that it is appropriate for our diet formulation procedures and can be done safely.

如果您需要在您的动物研究对象中添加或应用某些化合物，请使用客户提供的成分提交表。

一些常见的客户提供的化合物包括：

Cuprizone（现在也有库存）
他莫昔芬（现在也有库存：美国、欧盟）
纯化脂肪酸（DHA、EPA）
姜黄素
罗格列酮
他汀类药物
抗生素
丙戊酸盐
吡罗昔康
浆果粉
双酚 A（BPA，稀释形式）
在饮食中添加化合物时，我们将与您一起确保它适合我们的饮食配方程序并且可以安全地进行。

We require a safety data sheet or other relevant safety and usage information
We have an obligation to maintain a safe work environment. This typically applies to drugs, experimental compounds and chemicals
Food products generally will not require safety information, although information about nutrient content, reason for use, etc. is helpful in the design of diets

Water is added as a pelleting aid. Pellets are formed under pressure but no external heat is applied
Sometimes the drying process can be modified if heat stability is questioned
It is your responsibility to determine the suitability of the compound for inclusion into a pelleted diet

If you require irradiation, we can customize most diets to be suitable for this sterilization process
Once your diet has been produced, we can send it for irradiation. The dose ranges from 20-50 kGy. Diets that are to be irradiated require an additional two weeks for shipment (four weeks total)
For diets that are to be irradiated, vacuum packaging may be beneficial. Both irradiation and vacuum packaging must be requested when ordering
We defer to you to determine the suitability of the compound for irradiation

Inform us on a g/kg diet or percentage basis, how much of the compound you want in the diet
If you need to calculate a dose based on animal body weight, we can help convert that to g/kg diet
Depending on the choice of base diet and the nature of the added ingredient(s), more than a ten percent dilution is generally not advisable
To limit differences between the control and experimental diets you may want to consider using a control diet that uses similar ingredients and has gone through the same production process

Send extra compound (approximately enough for one more kg than you have ordered) so that we can yield the desired amount of diet
If we have not received enough compound, we will use the entire amount and make as much diet as possible, unless special arrangements can be made

If you plan to use the compound more than once and stability with storage is not an issue, we can maintain an inventory for you and store it appropriately, per your instructions
Unless otherwise instructed, we will return any remaining compound with your shipment, but we do not dispose of the compound
If you would like your compound retained for future use, please supply us with a retention document

我们需要安全数据表或其他相关的安全和使用信息
我们有义务维护安全的工作环境。这通常适用于药物、实验化合物和化学品
食品通常不需要安全信息，尽管有关营养成分、使用原因等的信息有助于饮食设计

添加水作为制粒助剂。颗粒在压力下形成，但没有施加外部热量
如果热稳定性受到质疑，有时可以修改干燥过程
您有责任确定该化合物是否适合添加到颗粒状饮食中

如果您需要辐照，我们可以定制大多数适合这种灭菌过程的饮食
一旦您的饮食制作完成，我们就可以将其送去进行辐照。剂量范围为 20-50 kGy。要辐照的饮食需要额外的两周才能装运（总共四周）
对于要辐照的饮食，真空包装可能是有益的。订购时必须要求辐照和真空包装
我们会根据您来确定该化合物是否适合辐照

以 g/kg 饮食或百分比为基础告知我们您在饮食中需要多少化合物
如果您需要根据动物体重计算剂量，我们可以帮助您将其转换为 g/kg 饮食
根据基础饮食的选择和添加成分的性质，通常不建议稀释超过 10%
为了限制对照饮食和实验饮食之间的差异，您可能需要考虑使用使用相似成分并经历相同生产过程的对照饮食

发送额外的化合物（大约比您订购的多一公斤），以便我们可以产生所需的饮食量
如果我们没有收到足够的化合物，我们将使用全部量并尽可能多地节食，除非可以做出特殊安排

如果您计划多次使用该化合物并且储存稳定性不是问题，我们可以为您维护库存并根据您的指示适当储存
除非另有说明，否则我们将随您的货物退回任何剩余的化合物，但我们不会处理该化合物
如果您希望保留您的化合物以供将来使用，请向我们提供保留文件

Technical resources 技术文章

Custom research diet info sheet
Tamoxifen info sheet: US
Cuprizone info sheet
Incorporating Test Compounds in Lab Animal Diets

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定制

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正文中列出的所有试剂只能用于测试或研究，不能作为”药品”，”食品”，”家庭用品”等使用。
我司所销售的化学试剂、原料等所有产品（包括但不限于抗生素类、蛋白质类、试剂盒类产品等）仅限用于科学研究用途，不得作用于人体。

Harlan 基础混合物饲料Basal mixes

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 基础混合物饲料Basal mixes

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Basal mixes

You may want to add some specific ingredients in your own facility. In that case, Envigo provides basal mixes that are, by design, a starting point for additional inclusions. When you choose a basal mix diet, you simply add any ingredient(s) in a specific proportion that your require. The nutrient levels in our basal mix are adjusted to account for the dilution of the added ingredient(s), so that the final complete diet contains the desired nutrient levels.

TD.00235 Basal mix (93%); AIN-93G without fat
TD.88232 Basal mix (without 20% Oil)

您可能想在自己的设施中添加一些特定成分。在这种情况下，Envigo 会提供基础混合物，这些基础混合物在设计上是添加其他内含物的起点。当您选择基础混合饮食时，您只需按您需要的特定比例添加任何成分。我们的基础混合物中的营养水平会根据添加成分的稀释进行调整，以便最终的完整饮食包含所需的营养水平。

TD.00235 基础混合物（93%）； AIN-93G 无脂
TD.88232 基础混合物（不含 20% 油）

Here are some examples of how a basal mix could be helpful to you:

Leave all or a portion of the fat source out. The end user can add various fats and make multiple diets from one basal mix
Make fresh diet as needed for an unstable, hazardous, or limited supply ingredient
Add a different vitamin or mineral mix to the same basal mix to create a series of vitamin or mineral adjusted diets

If proper mixing equipment is available, and you have the capability to feed powder diet, basal mixes offer flexibility and economy.

以下是一些基础组合如何对您有所帮助的示例：

将全部或部分脂肪源排除在外。最终用户可以添加各种脂肪并从一种基础混合物中制作多种饮食
根据需要为不稳定、危险或供应有限的成分制作新鲜饮食
将不同的维生素或矿物质混合物添加到相同的基础混合物中，以创建一系列维生素或矿物质调整的饮食
如果有合适的混合设备，并且您有能力喂食粉状饲料，则基础混合物提供灵活性和经济性。

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上海金畔生物科技有限公司

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Harlan异黄酮调整饲料Isoflavone adjusted

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan异黄酮调整饲料Isoflavone adjusted

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Isoflavone adjusted

Isoflavones, a type of phytoestrogen, are found in soy protein. Most traditional standard diets have soybean meal as a major ingredient, and therefore are a significant source of isoflavones. Please refer to FAQ section for more information about phytoestrogens.

In contrast, casein-based purified diets such as AIN-76A, AIN-93G, AIN-93M, and formulas with similar ingredients, are essentially free of isoflavones. This type of diet is sometimes used for research that requires a minimal isoflavone background. This type of diet can be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

An alternative to a purified, casein-based diet is a natural ingredient diet from our global rodent diet line. Several diets in this line contain minimal isoflavone/phytoestrogen levels and are commonly used for research that requires a minimal isoflavone/phytoestrogen background. This type of diet can also be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

异黄酮是一种植物雌激素，存在于大豆蛋白中。大多数传统的标准饮食都以豆粕为主要成分，因此是异黄酮的重要来源。有关植物雌激素的更多信息，请参阅常见问题部分。

相比之下，基于酪蛋白的纯化饮食，如 AIN-76A、AIN-93G、AIN-93M 和具有类似成分的配方食品，基本上不含异黄酮。这种类型的饮食有时用于需要最低异黄酮背景的研究。这种类型的饮食可用作添加异黄酮（如染料木黄酮（由客户提供））的背景。

我们全球啮齿动物饮食系列的天然成分饮食是纯化的、以酪蛋白为基础的饮食的替代品。该系列中的几种饮食含有最低的异黄酮/植物雌激素水平，通常用于需要最低异黄酮/植物雌激素背景的研究。这种类型的饮食也可以用作添加异黄酮如染料木黄酮（由客户提供）的背景。

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上海金畔生物科技有限公司

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Harlan兔子、猪和其他物种的饮食饲料Rabbit, swine and other species diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan兔子、猪和其他物种的饮食饲料Rabbit, swine and other species diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Rabbit, swine and other species

The most common custom rabbit diets are those with a standard diet base and added cholesterol. Typically, the added cholesterol ranges from 0.25% to two percent. Additional fat can also be a feature of these formulas. To preserve pellet quality we recommend no more than six percent additional fat. Added fat is most often supplied as peanut oil, corn oil, coconut oil, or a combination. We recommend the Teklad base diets 2030 or 2031.

Rabbits do not readily consume purified diet. When specific nutrient manipulations are necessary, hybrid diets or at least some alfalfa meal inclusion is recommended. Contact us for formula examples or to discuss your specific needs.

最常见的定制兔子饮食是那些具有标准饮食基础和添加胆固醇的饮食。通常，添加的胆固醇范围为 0.25% 至 2%。额外的脂肪也可能是这些配方的一个特点。为了保持颗粒质量，我们建议添加不超过 6% 的脂肪。添加的脂肪通常以花生油、玉米油、椰子油或它们的组合形式提供。我们推荐 Teklad 基础日粮 2030 或 2031。

兔子不容易食用纯净的食物。当需要进行特定的营养操作时，建议使用混合饮食或至少添加一些苜蓿粉。联系我们获取配方示例或讨论您的具体需求。

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上海金畔生物科技有限公司

Most often, customized diets for swine feature natural ingredients with added fat and cholesterol. Here are three variations on this theme:

TD.92033 Swine diet (15% lard, 1.2% cholesterol)
TD.92052 Swine diet (15% lard, 1.5% cholesterol)
TD.93296 Swine diet (15% lard, two perecent cholesterol)

We recommend these diets in meal/powder form, as pellets are not very durable. Other natural ingredient and purified diets with various nutrient manipulations are available. Contact us for further information.

大多数情况下，猪的定制饮食以添加脂肪和胆固醇的天然成分为特色。以下是此主题的三个变体：

TD.92033 猪饲料（15% 猪油，1.2% 胆固醇）
TD.92052 猪饲料（15% 猪油，1.5% 胆固醇）
TD.93296 猪饲料（15% 猪油，2% 胆固醇）
我们推荐这些膳食/粉末形式的饮食，因为颗粒不是很耐用。其他天然成分和经过各种营养操作的纯化饮食可供选择。联系我们获取更多信息。

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上海金畔生物科技有限公司

The most common custom Guinea pig diets are those with a standard diet base (such as Teklad 2040 or 2041) and added cholesterol.

Guinea pigs do not readily consume purified diets, so when specific nutrient manipulations are necessary, hybrid diets (mixture of refined and natural ingredients) are recommended. At the very least it is advisable to retain some alfalfa meal in the diet. Contact us for further information.

最常见的定制豚鼠饮食是具有标准饮食基础（例如 Teklad 2040 或 2041）并添加胆固醇的饮食。

豚鼠不容易食用纯化的饮食，因此当需要进行特定的营养操作时，建议使用混合饮食（精制和天然成分的混合物）。至少建议在饮食中保留一些苜蓿粉。联系我们获取更多信息。

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上海金畔生物科技有限公司

Most times, diets that are developed for mice and rats are suitable for hamsters and gerbils, and vice versa. We may advise increasing specific nutrients in a purified diet for hamsters and gerbils. Contact us for further information.

大多数时候，为小鼠和大鼠开发的饮食适用于仓鼠和沙鼠，反之亦然。我们可能会建议在仓鼠和沙鼠的纯化饮食中增加特定的营养素。联系我们获取更多信息。

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上海金畔生物科技有限公司

Depending on the focus of your research, customized diet for non-human primates can contain natural ingredients, refined ingredients, or a mixture of both. Custom diets for primates often feature adjustments in fat type, fat level, and cholesterol. Contact us for further information.

根据您的研究重点，非人类灵长类动物的定制饮食可以包含天然成分、精制成分或两者的混合物。灵长类动物的定制饮食通常会调整脂肪类型、脂肪水平和胆固醇。联系我们获取更多信息。

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Harlan饲料AIN diet formulas

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan饲料AIN diet formulas

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

AIN diet formulas

These formulas are purified diets with commonly used refined ingredients. These basic formulas are often modified for a specific research purpose, such as altering the fat source, a vitamin or mineral level, or adding a compound. See the FAQ section to learn more about the history of these formulas, AIN-76A, AIN-93G, and AIN-93M.

这些配方是含有常用精制成分的纯化饮食。这些基本配方通常会针对特定的研究目的进行修改，例如改变脂肪来源、维生素或矿物质水平，或添加化合物。请参阅常见问题解答部分，详细了解这些公式 AIN-76A、AIN-93G 和 AIN-93M 的历史。

CA.170481 AIN-76A purified diet
TD.94045 AIN-93G purified diet
TD.94048 AIN-93M purified diet

AIN-93是由美国营养学会颁布的啮齿类实验动物纯化饲料标准，被广泛应用于不同类型的研究。AIN-93标准饲料分为M和G型，M型适用于维持期，G型适用于生长/繁殖期。定制该系列饲料时，可生产固定配方的AIN-93标准饲料，亦可根据实验需求进行营养素的调整。

AIN-93标准饲料对比AIN-76标准饲料的配方改良
1977-1980年，美国营养研究所发布了纯化型啮齿动物饲料标准配方——AIN-76A，而后在世界各地被广泛使用。但在此期间AIN-76标准饲料也遇到许多营养方面的问题，直到1993年，美国营养研究所才发布了可替代AIN-76A的两种饲料配方：用于生长、妊娠和哺乳期的AIN-93G和用于成年维持期的AIN-93M.

AIN-93系列饲料配方主要的变化包括用玉米淀粉代替蔗糖，用大豆油代替玉米油，并增加用量以供应必需脂肪酸（亚油酸和亚麻酸）；用L-胱氨酸代替DL-蛋氨酸以补充酪蛋白成分；重新配制矿物混合物，以降低磷、锰和铬的含量，增加硒的含量，并添加钼、硅、氟化物、镍、硼、锂和钒；维生素E、K-1和B-12的含量均高于AIN-76A维生素混合物中的含量。AIN-93G标准饲料每千克含有200克酪蛋白和70克大豆油，AIN-93M标准饲料每千克含有140克酪蛋白和40克大豆油。

AIN-93系列饲料相比AIN-76A饲料具有更好的营养平衡，是目前实验室啮齿动物营养研究的更佳选择。

产品形状：棒状颗粒（如有特殊需求可以提供粉料等）

储存方式：4℃冷藏（建议）或常温

保质期：6个月

建议采购量：小鼠按照5克/只/天计算；大鼠按照30克/只/天计算

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上海金畔生物科技有限公司

These formulas (as well as other purified diets) do not contain alfalfa and can be used to reduce background autofluorescence in certain imaging applications. Our Global Rodent Diets are also alfalfa-free and are suitable for imaging work. Please contact us for further information about these formulas or modifications.

这些配方（以及其他纯化饮食）不含紫花苜蓿，可用于减少某些成像应用中的背景自发荧光。我们的全球啮齿动物饮食也不含苜蓿，适用于成像工作。请联系我们以获取有关这些公式或修改的更多信息。

Other related product codes:

TD.94096 version of AIN-76A suitable for irradiation (vitamin levels are increased)
TD.97184 version of AIN-93G suitable for irradiation (vitamin levels are increased)
TD.00102 version of AIN-93M suitable for irradiation (vitamin levels are increased)
TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil

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Harlan 全球 14% 蛋白质啮齿动物维持饮食2014 Teklad global 14% protein rodent maintenance diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 全球 14% 蛋白质啮齿动物维持饮食2014 Teklad global 14% protein rodent maintenance diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

2014 Teklad global 14% protein rodent maintenance diets

Product Features

Designed to promote longevity and normal body weight
Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity

Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

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Products

Teklad rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad global 14% protein	2014 , 2014C	2014S	2914

Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.

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Harlan 全球 16% 蛋白质啮齿动物饮食2016 Teklad global 16% protein rodent diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 全球 16% 蛋白质啮齿动物饮食2016 Teklad global 16% protein rodent diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

2016 Teklad global 16% protein rodent diets

Product Features

Designed to support growth and maintenance
Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity

Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

产品特点

旨在支持增长和维护
配方不含豆粕，从而最大限度地减少异黄酮的存在，异黄酮是实验室动物饮食中发现的主要植物雌激素类型
典型的异黄酮浓度（黄豆苷元 + 金雀异黄苷元当量）范围从不可检测到 20 mg/kg
排除紫花苜蓿可减少叶绿素，大大提高荧光光学成像清晰度
不含动物蛋白和鱼粉可最大限度地减少亚硝胺（一种潜在的致癌物质）的存在

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Products

Teklad rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad global 16% protein	2016 , 2016C	2016S	2916

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图片仅供参考,请以实物为准。

Harlan 全球 18% 蛋白质啮齿动物饮食2018 Teklad global 18% protein rodent diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 全球 18% 蛋白质啮齿动物饮食2018 Teklad global 18% protein rodent diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

2018 Teklad global 18% protein rodent diets

Product Features

Designed to support gestation, lactation, and growth
Formulated to reduce soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from 150 to 250 mg/kg
Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity
Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

产品特点

旨在支持妊娠、哺乳和生长
配方可减少豆粕，从而最大限度地减少异黄酮的存在，异黄酮是实验室动物饮食中发现的主要植物雌激素类型
典型的异黄酮浓度（黄豆苷元 + 金雀异黄苷元当量）范围为 150 至 250 mg/kg
排除紫花苜蓿可减少叶绿素，大大提高荧光光学成像清晰度
不含动物蛋白和鱼粉可最大限度地减少亚硝胺（一种潜在的致癌物质）的存在

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上海金畔生物科技有限公司

Products

Teklad rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad global 18% protein	2018 , 2018C	2018S , 2018SX	2918

Technical resources 技术文章

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Harlan 全球 19% 蛋白质挤压啮齿动物饲料 2019 Teklad global 19% protein extruded rodent diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 全球 19% 蛋白质挤压啮齿动物饲料 2019 Teklad global 19% protein extruded rodent diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

2019 Teklad global 19% protein extruded rodent diets

Product Features

Designed to support gestation, lactation, and growth of rodents
Useful for poorly breeding strains of rodents and genetically engineered stocks and strains
Extruded form ensures that despite its high fat content, it remains firm with minimal wastage
Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity

Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

产品特点

旨在支持啮齿动物的妊娠、哺乳和生长
适用于啮齿动物和基因工程种群和菌株的不良繁殖品系
挤压形式可确保尽管脂肪含量高，但仍能保持牢固，减少浪费
配方不含豆粕，从而最大限度地减少异黄酮的存在，异黄酮是实验室动物饮食中发现的主要植物雌激素类型
典型的异黄酮浓度（黄豆苷元 + 金雀异黄苷元当量）范围从不可检测到 20 mg/kg
排除紫花苜蓿可减少叶绿素，大大提高荧光光学成像清晰度
不含动物蛋白和鱼粉可最大限度地减少亚硝胺（一种潜在的致癌物质）的存在

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18301939375

上海金畔生物科技有限公司

Products

Teklad rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad global 19% protein extruded	2019	2019S	2919

Technical resources 技术文章

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Harlan 无大豆蛋白膨化啮齿动物饲料 2020X Teklad global soy protein-free extruded rodent diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 无大豆蛋白膨化啮齿动物饲料 2020X Teklad global soy protein-free extruded rodent diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

2020X Teklad global soy protein-free extruded rodent diets

Product Features

Designed to support gestation, lactation, and growth of rodents
Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity

Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

产品特点

旨在支持啮齿动物的妊娠、哺乳和生长
配方不含豆粕，从而最大限度地减少异黄酮的存在，异黄酮是实验室动物饮食中发现的主要植物雌激素类型
典型的异黄酮浓度（黄豆苷元 + 金雀异黄苷元当量）范围从不可检测到 20 mg/kg
排除紫花苜蓿可减少叶绿素，大大提高荧光光学成像清晰度
不含动物蛋白和鱼粉可最大限度地减少亚硝胺（一种潜在的致癌物质）的存在

order today

18301939375

上海金畔生物科技有限公司

Products

Teklad rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad global soy protein-free extruded	2020X	2020SX	2920X

Technical resources 技术文章

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Harlan 传统啮齿动物饮食Traditional rodent diets

发表于2022年1月13日由上海金畔生物科技有限公司

Harlan 传统啮齿动物饮食Traditional rodent diets

Harlan Teklad动物饲料
欢迎新老客户访问Harlan官网或者咨询上海金畔生物获取更多详细资料。

Traditional rodent diets

Traditional rodent diets were formulated decades ago based on understanding of rodent nutrition, ingredients, and diet manufacturing at the time. While traditional diets will supply the known nutrient needs of your laboratory animals, we recommend you consider the use of a diet from our newer Teklad Global Rodent Diet^® line for your modern research needs.

传统的啮齿动物饮食是几十年前基于对当时啮齿动物营养、成分和饮食制造的了解而制定的。虽然传统饮食将满足您的实验动物已知的营养需求，但我们建议您考虑使用我们更新的 Teklad Global Rodent Diet® 系列的饮食来满足您的现代研究需求。

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Products

Teklad traditional rodent diets	Non-autoclavable form	Autoclavable	Irradiated
Teklad S-2335 mouse breeder sterilizable diet		7004	7904
Teklad LM-485 mouse/rat sterilizable diet		7012	7912
NIH-31 Modified Open Formula Mouse/Rat sterilizable diet		7013	7913
NIH-31 Open formula mouse/rat sterilizable diet		7017	7917
NIH-07 Mouse/rat diet	7022		7922
Teklad low salt mouse/rat sterilizable diet		7034
Teklad rodent diet	8904 , 8604

并非所有产品都在当地备货；可能需要延长交货时间和额外费用。
许多饮食都可以通过产品代码后面的“C”指定的认证格式获得。当日粮获得认证时，会针对一组污染物对代表性样本进行测试。如果库存没有经过认证，可根据要求提供认证。最小订单量和额外费用可能适用。

Technical resources 技术文章

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