Biotin functionalized polyethylene glycol (PEG-Biotin) is an avidin or streptavidin binding PEG derivative that is used to biotinylate biomolecules or other material surfaces. Biotin can be easily detected by biotin/streptavidin binding assay and is widely used for molecule target detection.

Biotin PEG Amine (Biotin-PEG-NH2) is one of Nanocs reactive PEG biotin reagents that have a biotin tag on one PEG end and a primary amine group on the other PEG terminus. Biotin PEG NH2 can be used to modify other molecules or surfaces via its reactive primary amine group. Primary amine reacts readily with NHS ester, carboxylic acids and many other functional groups. Reactions btween amine and other groups allows rapid attachement of biotin tag to targeted molecules or material surfaces. Resulted biotin tag can be easily detected with avidin or streptavidin. PEG linker between NH2 and Biotin offers better water solubility, flexible linker structure and enhanced stability.