描述
Deoxyarbutin 脱氧熊果苷
产品标签
Deoxyarbutin 脱氧熊果苷；β-Arbutin β-熊果苷；Tyrosinase inhibitor 酪氨酸酶抑制剂；Melanin production inhibitor 黑色素生成抑制剂；Polyphenol Oxidase 蘑菇多酚氧化酶；CAS：53936-56-4；
产品信息
| 产品名称 | 产品编号 | 规格 | 价格（元） |
| Deoxyarbutin 脱氧熊果苷 | MZ95033-1G | 1g | 360 |
| Deoxyarbutin 脱氧熊果苷 | MZ95033-5G | 5g | 780 |
产品描述
脱氧熊果苷（Deoxyarbutin，CAS：53936-56-4）是一种有效且可逆的酪氨酸酶抑制剂（IC50=50nM）。能抑制黑色素合成，引起明显和长期的皮肤增白效果。
产品特性
1） CAS NO：53936-56-4
2） 化学名：4-(Oxan-2-yloxy)phenol
3） 分子式：C11H14O3
4） 分子量：194.23
5） 纯度：≥99%
6） 外观：白色或类白色粉末
7） 溶解性：溶于DMSO（100mM）、乙醇（100mM）、不溶于水
8） 化学结构图：
保存与运输方法
保存：-20ºC干燥保存，至少2年有效。
运输：室温运输
注意事项
1） 本品不是临床药物，只能用于科研用途，不能用于诊断或临床用途。
2） 为了您的安全和健康，请穿实验服并戴一次性手套操作。
配制储存液
| 质量
溶剂体积 浓度 |
1mg | 5mg | 10mg | 100mg |
| 1mM | 5.1485 mL | 25.7427 mL | 51.4854 mL | 514.8535 mL |
| 5mM | 1.0297 mL | 5.1485 mL | 10.2971 mL | 102.9707 mL |
| 10mM | 0.5149 mL | 2.5743 mL | 5.1485 mL | 51.4854 mL |
| 50mM | 0.1030 mL | 0.5149 mL | 1.0297 mL | 10.2971 mL |
使用方法【源自文献，仅作参考】
| 文献1，Boissy RE et al.DeoxyArbutin: A novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.Exp Dermatol. 2005 Aug;14(8):601-8. PMID: 16026582
体内研究（动物）： 动物模型（Animal Model）：Hairless pigmented (black) guinea pig models 药物配制（Preparation）：dA (DeoxyArbutin) was prepared in I base cream consisting of water (25%), 0.2M triethanolamine hydrochloride (44.5%), glycerin (3.75%), Parson MCX (7.5%), cutina GMS (2.5%), and tegin 90 (2.5%). 实验方法（Assay）：For experiments comparing skin lightening effects of test compounds, skin was treated daily for 9 weeks with dA, Hydroquinone (HQ), kojic acid and arbutin (3%) in I base cream. Ten animals were in each treatment group, and three independent experiments were performed. Skin lightness was measured at baseline and then weekly with a colorimeter. 实验结果（Results）：Both dA and HQ resulted in skin lightening during the initial 3 weeks of treatment, the extent of dA-induced skin lightening plateaued while the HQ-treated skin darkened and returned to the pretreatment value. The dA treated sites showed no signs of skin irritation. In contrast, HQ treated skin showed signs of irritation that resulted in irregular darkening, beginning at 3 weeks of treatment. In contrast, kojic acid, and arbutin were not significantly different from the vehicle control. |
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| 文献2，Chawla S et al. Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.. Br J Dermatol. 2008 Dec;159(6):1267-74. PMID:18811684
体内研究（细胞）： 细胞类型（Cell type）：Human melanocytes 药物配制（Preparation）：All compounds (dA, dF, fdA, tdA and HQ) were dissolved in sterile DMSO. Stock solutions of compounds were prepared and protected from light at -20℃until use. At time of use, compounds were further diluted in growth medium to produce the final required concentration. Compounds were tested at the appropriate concentration range (1-100μM) in triplicate in order to calculate LD50values. 实验方法（Assay）：Melanocytes were seeded at 1-3×105cells and allowed to grow for 48h before treatment. Cultured were treated daily with fresh growth media containing test compound for 5 days. On the sixth day, cells were detached and counted. 实验结果（Results）：A concentration-dependent decrease in the cell number of both was observed for all inhibitors (dA, dF, fdA, tdA and HQ). LD50concentrations of dA and its derivatives are listed below.
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| MZ95032-1G | alpha-Arbutin alpha-熊果苷 | 1g |
| MZ95033-1G | Deoxyarbutin 脱氧熊果苷 | 1g |
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